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Fatty acid metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(3S)-3-hydroxytetradecanoyl-CoA <=> 2-tetradecenoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase


(S)-3-hydroxydecanoyl-CoA <=> trans-2-decenoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase


acetyl-CoA + myristoyl-CoA <=> CoA + 3-ketohexadecanoyl-CoA 2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase


(4Z,7Z,10Z,13Z,16Z)-Docosapentaenoyl-CoA + acetyl-CoA <=> (6Z,9Z,12Z,15Z,18Z)-3-Oxotetracosapentaenoyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.176 propanoyl-CoA C-acyltransferase


L-3-hydroxydodecanoyl-CoA <=> trans-2-dodecenoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase


decanoyl-CoA + acetyl-CoA <=> 3-oxododecanoyl-CoA + CoA 2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase


trans-2-decenoyl-CoA + NADPH <=> decanoyl-CoA + NADP+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)


octanoyl-CoA + acetyl-CoA <=> 3-oxodecanoyl-CoA + CoA 2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase


(3R)-3-hydroxymyristoyl-[acyl-carrier_protein] <=> trans-Tetradec-2-enoyl-[acp] + H2O 2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
4.2.1
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase





tetradecanoyl-[acyl-carrier_protein] + NADP+ <=> trans-Tetradec-2-enoyl-[acp] + NADPH + H+ 1.3.1
1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system






(3R)-3-hydroxypalmitoyl-[acyl-carrier_protein] + NADP+ <=> 3-oxohexadecanoyl-[acyl-carrier_protein] + NADPH + H+ 1.1.1
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





butyryl-[acyl-carrier_protein] + malonyl-[acyl-carrier_protein] + H+ <=> 3-oxohexanoyl-[acyl-carrier_protein] + CO2 + [acyl-carrier_protein] 2.3.1
2.3.1.179 beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





(3R)-3-hydroxybutanoyl-[acyl-carrier_protein] + NADP+ <=> acetoacetyl-[acyl-carrier_protein] + NADPH + H+ 1.1.1
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





fatty_acid + CoA + ATP <=> stearoyl-CoA + AMP + diphosphate 1.13.12.7 firefly luciferase
6.2.1.12 4-coumarate---CoA ligase
6.2.1.3 long-chain-fatty-acid---CoA ligase
6.2.1.30 phenylacetate---CoA ligase
6.2.1.B3





(S)-3-hydroxydecanoyl-CoA + NAD+ <=> 3-oxodecanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


stearoyl-CoA + NADP+ <=> trans-2-octadecenoyl-CoA + NADPH + H+ 1.3.1
1.3.1.93 very-long-chain enoyl-CoA reductase


acetyl-CoA + malonyl-[acyl-carrier_protein] + H+ <=> acetoacetyl-[acyl-carrier_protein] + CoA + CO2 2.3.1.180 beta-ketoacyl-[acyl-carrier-protein] synthase III

stearoyl-[acyl-carrier_protein] + NAD+ <=> (2E)-Octadecenoyl-[acp] + NADH + H+ 1.3.1
1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
2.3.1



(S)-3-hydroxyhexanoyl-CoA <=> trans-2-hexenoyl-CoA + H2O 4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase



butyryl-[acyl-carrier_protein] + NAD+ <=> trans-but-2-enoyl-[acyl-carrier_protein] + NADH + H+ 1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
2.3.1


(3S)-hydroxyhexadecanoyl-CoA + NAD+ <=> 3-ketohexadecanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


(8Z,11Z)-Icosadienoyl-CoA + 2 ferricytochrome_b5 + O2 + 2 H+ <=> 5,8,11-eicosatrienoyl-CoA + 2 ferricytochrome_b5 + 2 H2O 1.14.19.44 acyl-CoA (8-3)-desaturase

palmitoyl-CoA + H2O <=> H+ + palmitate + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
3.1.1.1 carboxylesterase
3.1.1.23 acylglycerol lipase
3.1.1.5 lysophospholipase
3.1.2
3.1.2.1 acetyl-CoA hydrolase
3.1.2.2 palmitoyl-CoA hydrolase
3.1.2.20 acyl-CoA hydrolase
3.1.2.22 palmitoyl[protein] hydrolase
3.1.2.25 phenylacetyl-CoA hydrolase










2-decenoyl-[acyl-carrier_protein] + NADPH <=> decanoyl-[acyl-carrier_protein] + NADP+ 1.3.1
1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system






L-3-hydroxydodecanoyl-CoA + NAD+ <=> 3-oxododecanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


octanoyl-CoA + FAD <=> 2-octenoyl-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.8.8 long-chain acyl-CoA dehydrogenase
1.3.99




decanoyl-CoA + FAD <=> trans-2-decenoyl-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.8.8 long-chain acyl-CoA dehydrogenase
1.3.99




(S)-3-hydroxyoctanoyl-CoA <=> 2-octenoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase


(3R)-3-hydroxydecanoyl-[acyl-carrier_protein] + NADP+ <=> 3-oxodecanoyl-[acyl-carrier_protein] + NADPH + H+ 1.1.1
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





(R)-3-hydroxydodecanoyl-[acyl-carrier_protein] <=> dodecenoyl-[Staphylococcus_aureus_acyl_carrier_protein] + H2O 2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
4.2.1
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase





(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosaheptaenoyl-CoA + H2O2 1.3.3.6 acyl-CoA oxidase

oleoyl-CoA + ferricytochrome_b5 + O2 + H+ <=> linoleoyl-CoA + ferricytochrome_b5 + H2O 1.14.19.22 acyl-lipid omega-6 desaturase (cytochrome b5)
1.14.19.6 acyl-CoA (9+3)-desaturase


hexanoyl-[acyl-carrier_protein] + NADP+ <=> trans-Hex-2-enoyl-[acp] + NADPH + H+ 1.3.1
1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system






tetradecanoyl-[acyl-carrier_protein] + NAD+ <=> trans-Tetradec-2-enoyl-[acp] + NADH + H+ 1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
2.3.1


malonyl-CoA + palmitoyl-CoA + H+ <=> 3-oxostearoyl-CoA + CO2 + CoA 2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase

trans-2-dodecenoyl-CoA + NADPH <=> lauroyl-CoA + NADP+ 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)




malonyl-CoA + [acyl-carrier_protein] <=> CoA + malonyl-[acyl-carrier_protein] 2.3.1
2.3.1.39 [acyl-carrier-protein] S-malonyltransferase
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system




butyryl-[acyl-carrier_protein] + NADP+ <=> trans-but-2-enoyl-[acyl-carrier_protein] + NADPH + H+ 1.3.1
1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system






lauroyl-CoA + acetyl-CoA <=> 3-oxotetradecanoyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase

stearoyl-CoA + ferricytochrome_b5 + O2 + H+ <=> oleoyl-CoA + ferricytochrome_b5 + H2O 1.14.19.1 stearoyl-CoA 9-desaturase

(3R)-3-hydroxyhexanoyl-[acyl-carrier_protein] + NADP+ <=> 3-oxohexanoyl-[acyl-carrier_protein] + NADPH + H+ 1.1.1
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





2-tetradecenoyl-CoA + NADPH <=> myristoyl-CoA + NADP+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)


ATP + acetyl-CoA + HCO3- <=> ADP + phosphate + malonyl-CoA + H+ 6.4.1.2 acetyl-CoA carboxylase
6.4.1.3 propionyl-CoA carboxylase
6.4.1.4 methylcrotonoyl-CoA carboxylase



acetyl-[acyl-carrier_protein] + malonyl-[acyl-carrier_protein] + H+ <=> [acyl-carrier_protein] + acetoacetyl-[acyl-carrier_protein] + CO2 2.3.1
2.3.1.179 beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





(3R,6Z,9Z,12Z,15Z,18Z)-3-Hydroxytetracosapentaenoyl-CoA <=> (2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexaenoyl-CoA + H2O 4.2.1.119 enoyl-CoA hydratase 2

(3R)-3-hydroxybutanoyl-[acyl-carrier_protein] <=> trans-but-2-enoyl-[acyl-carrier_protein] + H2O 2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
4.2.1
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase





(3S)-3-hydroxytetradecanoyl-CoA + NAD+ <=> 3-oxotetradecanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


(9Z,12Z,15Z,18Z,21Z)-Tetracosapentaenoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> (6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA + H2O + ferricytochrome_b5 1.14.19.3 acyl-CoA 6-desaturase

dodecanoyl-[acyl-carrier_protein] + NAD+ <=> dodecenoyl-[Staphylococcus_aureus_acyl_carrier_protein] + NADH + H+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
2.3.1




(S)-3-hydroxyhexanoyl-CoA + NAD+ <=> 3-oxohexanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


(R)-3-hydroxystearoyl-[acyl-carrier_protein] <=> (2E)-Octadecenoyl-[acp] + H2O 2.3.1
4.2.1


acetyl-CoA + [acyl-carrier_protein] <=> CoA + acetyl-[acyl-carrier_protein] 2.3.1
2.3.1.180 beta-ketoacyl-[acyl-carrier-protein] synthase III
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.39 [acyl-carrier-protein] S-malonyltransferase
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
2.7.8.7 holo-[acyl-carrier-protein] synthase







hexanoyl-[acyl-carrier_protein] + malonyl-[acyl-carrier_protein] + H+ <=> 3-oxooctanoyl-[acyl-carrier_protein] + CO2 + [acyl-carrier_protein] 2.3.1
2.3.1.179 beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





(3R,6Z,9Z,12Z,15Z,18Z)-3-Hydroxytetracosapentaenoyl-CoA + NAD+ <=> (6Z,9Z,12Z,15Z,18Z)-3-Oxotetracosapentaenoyl-CoA + NADH + H+ 1.1.1

palmitoyl-[acyl-carrier_protein] + H2O <=> fatty_acid + [acyl-carrier_protein] + H+ 2.3.1.85 fatty-acid synthase system
3.1.2.14 oleoyl-[acyl-carrier-protein] hydrolase
3.1.2.21 dodecanoyl-[acyl-carrier-protein] hydrolase



dodecanoyl-[acyl-carrier_protein] + NADP+ <=> dodecenoyl-[Staphylococcus_aureus_acyl_carrier_protein] + NADPH + H+ 1.3.1
1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system






(S)-3-hydroxybutyryl-CoA + NAD+ <=> acetoacetyl-CoA + NADH + H+ 1.1.1.178 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase
1.1.1.36 acetoacetyl-CoA reductase



octanoyl-[acyl-carrier_protein] + NADP+ <=> 2-octenoyl-[acyl-carrier_protein] + NADPH + H+ 1.3.1
1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system






(6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexaenoyl-CoA + H2O2 1.3.3.6 acyl-CoA oxidase

butyryl-CoA + acetyl-CoA <=> 3-oxohexanoyl-CoA + CoA 2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase



oleoyl-CoA + 2 ferricytochrome_b5 + O2 + 2 H+ <=> (6Z,9Z)-Octadecadienoyl-CoA + 2 ferricytochrome_b5 + 2 H2O 1.14.19.3 acyl-CoA 6-desaturase

palmitoyl-CoA + L-carnitine <=> O-palmitoyl-L-carnitine + CoA 2.3.1.137 carnitine O-octanoyltransferase
2.3.1.21 carnitine O-palmitoyltransferase
2.3.1.7 carnitine O-acetyltransferase



ATP + alpha,omega-dicarboxylate + CoA <=> malonyl-CoA + AMP + diphosphate 6.2.1
6.2.1.23 dicarboxylate---CoA ligase


(3S)-hydroxyhexadecanoyl-CoA <=> trans-2-hexadecenoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase
4.2.1.74 long-chain-enoyl-CoA hydratase


palmitoyl-[acyl-carrier_protein] + CoA <=> palmitoyl-CoA + [acyl-carrier_protein] 2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system



8,11,14-eicosatrienoic_acid + O2 + ferricytochrome_b5 + H+ <=> Arachidonoyl-CoA + H2O + ferricytochrome_b5 1.14.19.44 acyl-CoA (8-3)-desaturase

linoleoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> gamma-linolenoyl-CoA + H2O + ferricytochrome_b5 1.14.19.3 acyl-CoA 6-desaturase

palmitoyl-[acyl-carrier_protein] + NADP+ <=> trans-Hexadec-2-enoyl-[acp] + NADPH + H+ 1.3.1
1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system






butyryl-CoA + FAD <=> crotonyl-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
1.3.8.1 short-chain acyl-CoA dehydrogenase
1.3.8.4 isovaleryl-CoA dehydrogenase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.99





3-hydroxystearoyl-CoA <=> trans-2-octadecenoyl-CoA + H2O 4.2.1.119 enoyl-CoA hydratase 2
4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase


(3R,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-CoA <=> (2E,6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosaheptaenoyl-CoA + H2O 4.2.1.119 enoyl-CoA hydratase 2

octanoyl-[acyl-carrier_protein] + malonyl-[acyl-carrier_protein] + H+ <=> 3-oxodecanoyl-[acyl-carrier_protein] + CO2 + [acyl-carrier_protein] 2.3.1
2.3.1.179 beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





myristoyl-CoA + FAD <=> 2-tetradecenoyl-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.8.8 long-chain acyl-CoA dehydrogenase
1.3.8.9 very-long-chain acyl-CoA dehydrogenase
1.3.99





(3R)-3-hydroxydecanoyl-[acyl-carrier_protein] <=> 2-decenoyl-[acyl-carrier_protein] + H2O 2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
4.2.1
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase





octanoyl-[acyl-carrier_protein] + NAD+ <=> 2-octenoyl-[acyl-carrier_protein] + NADH + H+ 1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
2.3.1


3-hydroxystearoyl-CoA + NADP+ <=> 3-oxostearoyl-CoA + NADPH + H+ 1.1.1
1.1.1.330 very-long-chain 3-oxoacyl-CoA reductase


palmitoyl-CoA + NADP+ <=> trans-2-hexadecenoyl-CoA + NADPH + H+ 1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)


linolenoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> stearidonoyl-CoA + H2O + ferricytochrome_b5 1.14.19.3 acyl-CoA 6-desaturase

acetyl-CoA <=> acetoacetyl-CoA + CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase





decanoyl-[acyl-carrier_protein] + malonyl-[acyl-carrier_protein] + H+ <=> 3-oxododecanoyl-[acyl-carrier_protein] + CO2 + [acyl-carrier_protein] 2.3.1
2.3.1.179 beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





2-decenoyl-[acyl-carrier_protein] + NADH <=> decanoyl-[acyl-carrier_protein] + NAD+ 1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
2.3.1


(3R)-3-hydroxyoctanoyl-[acyl-carrier_protein] + NADP+ <=> 3-oxooctanoyl-[acyl-carrier_protein] + NADPH + H+ 1.1.1
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





palmitoyl-[acyl-carrier_protein] + malonyl-[acyl-carrier_protein] + H+ <=> 3-oxooctadecanoyl-[acyl-carrier_protein] + CO2 + [acyl-carrier_protein] 2.3.1
2.3.1.179 beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.199 very-long-chain 3-oxoacyl-CoA synthase
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I




(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> eicosapentaenoyl-CoA + H2O + ferricytochrome_b5 1.14.19.44 acyl-CoA (8-3)-desaturase

lauroyl-CoA + FAD <=> trans-2-dodecenoyl-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.8.8 long-chain acyl-CoA dehydrogenase
1.3.99




stearoyl-[acyl-carrier_protein] + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> oleoyl-[acyl-carrier_protein] + oxidized_ferredoxin + H2O 1.14.19.2 stearoyl-[acyl-carrier-protein] 9-desaturase

(S)-3-hydroxybutyryl-CoA <=> H2O + crotonyl-CoA 1.3.8.7 medium-chain acyl-CoA dehydrogenase
4.2.1.116 3-hydroxypropionyl-CoA dehydratase
4.2.1.150 short-chain-enoyl-CoA hydratase
4.2.1.17 enoyl-CoA hydratase




eicosenoyl-CoA + 2 ferricytochrome_b5 + O2 + 2 H+ <=> (8Z,11Z)-Icosadienoyl-CoA + 2 ferricytochrome_b5 + 2 H2O 1.14.19.3 acyl-CoA 6-desaturase

(3R)-3-hydroxymyristoyl-[acyl-carrier_protein] + NADP+ <=> 3-oxotetradecanoyl-[acyl-carrier_protein] + NADPH + H+ 1.1.1
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





(3R)-3-hydroxypalmitoyl-[acyl-carrier_protein] <=> trans-Hexadec-2-enoyl-[acp] + H2O 2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
4.2.1
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase





(9Z,12Z,15Z,18Z)-Tetracosatetraenoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> (6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA + H2O + ferricytochrome_b5 1.14.19.3 acyl-CoA 6-desaturase

dodecanoyl-[acyl-carrier_protein] + malonyl-[acyl-carrier_protein] + H+ <=> 3-oxotetradecanoyl-[acyl-carrier_protein] + CO2 + [acyl-carrier_protein] 2.3.1
2.3.1.179 beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





hexanoyl-CoA + acetyl-CoA <=> 3-oxooctanoyl-CoA + CoA 2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase


(3R)-3-hydroxyoctanoyl-[acyl-carrier_protein] <=> 2-octenoyl-[acyl-carrier_protein] + H2O 2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
4.2.1
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase





(11Z,14Z,17Z)-icosa-11,14,17-trienoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + H2O + ferricytochrome_b5 1.14.19
1.14.19.3 acyl-CoA 6-desaturase


palmitoyl-CoA + FAD <=> trans-2-hexadecenoyl-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.8.8 long-chain acyl-CoA dehydrogenase
1.3.8.9 very-long-chain acyl-CoA dehydrogenase
1.3.99





palmitoyl-[acyl-carrier_protein] + NAD+ <=> trans-Hexadec-2-enoyl-[acp] + NADH + H+ 1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
2.3.1


docosahexaenoyl-CoA + acetyl-CoA <=> (6Z,9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosahexaenoyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.176 propanoyl-CoA C-acyltransferase


linoleoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> linolenoyl-CoA + H2O + ferricytochrome_b5 1.14.19
1.14.19.13 acyl-CoA 15-desaturase


(S)-3-hydroxyoctanoyl-CoA + NAD+ <=> 3-oxooctanoyl-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


stearoyl-CoA + NADPH + O2 + H+ <=> oleoyl-CoA + NADP+ + H2O 1.14.19
1.14.19.1 stearoyl-CoA 9-desaturase
1.14.19.M26



3-oxooctadecanoyl-[acyl-carrier_protein] + NADPH + H+ <=> (R)-3-hydroxystearoyl-[acyl-carrier_protein] + NADP+ 1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
2.3.1


(3R)-3-hydroxyhexanoyl-[acyl-carrier_protein] <=> trans-Hex-2-enoyl-[acp] + H2O 2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system
4.2.1
4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase





(3R,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-CoA + NAD+ <=> (6Z,9Z,12Z,15Z,18Z,21Z)-3-Oxotetracosahexaenoyl-CoA + NADH + H+ 1.1.1

hexanoyl-[acyl-carrier_protein] + NAD+ <=> trans-Hex-2-enoyl-[acp] + NADH + H+ 1.3.1.9 enoyl-[acyl-carrier-protein] reductase (NADH)
2.3.1


tetradecanoyl-[acyl-carrier_protein] + malonyl-[acyl-carrier_protein] + H+ <=> 3-oxohexadecanoyl-[acyl-carrier_protein] + CO2 + [acyl-carrier_protein] 2.3.1
2.3.1.179 beta-ketoacyl-[acyl-carrier-protein] synthase II
2.3.1.41 beta-ketoacyl-[acyl-carrier-protein] synthase I
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





trans-2-hexenoyl-CoA + NADPH <=> hexanoyl-CoA + NADP+ 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.44 trans-2-enoyl-CoA reductase (NAD+)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)




2-octenoyl-CoA + NADPH <=> octanoyl-CoA + NADP+ 1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.38 trans-2-enoyl-CoA reductase (NADPH)
1.3.1.8 acyl-CoA dehydrogenase (NADP+)



(11Z,14Z)-icosa-11,14-dienoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> 8,11,14-eicosatrienoic_acid + H2O + ferricytochrome_b5 1.14.19
1.14.19.3 acyl-CoA 6-desaturase


(R)-3-hydroxydodecanoyl-[acyl-carrier_protein] + NADP+ <=> 3-oxododecanoyl-[acyl-carrier_protein] + NADPH + H+ 1.1.1
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





hexanoyl-CoA + FAD <=> trans-2-hexenoyl-CoA + FADH2 1.3.3.6 acyl-CoA oxidase
1.3.8.1 short-chain acyl-CoA dehydrogenase
1.3.8.4 isovaleryl-CoA dehydrogenase
1.3.8.7 medium-chain acyl-CoA dehydrogenase
1.3.8.8 long-chain acyl-CoA dehydrogenase
1.3.99






Visualization of the pathway